Postoperative hormonal therapy prevents recovery of neurological damage after surgery in patients with breast cancer
نویسندگان
چکیده
Cancer survivors are exposed to several risk factors for cognitive dysfunction, such as general anesthesia, surgical trauma, and adjuvant therapies. In our recent study we showed that thalamic volume reduction and attentional dysfunction occurred shortly after surgery. Here, we examined the 6-month prognosis of the 20 patients with breast cancer who underwent surgery. Seven patients did not receive any adjuvant therapy after the surgery and 13 patients received a hormonal therapy after the surgery. We assessed their attentional functions, and thalamic volumes shortly after and 6 months after surgery. We found a significant group x time interaction in the attentional functions (p = 0.033) and the right thalamus (p < 0.05, small volume correction), suggesting the thalamic volume reduction and attentional dysfunction recovered in patients without adjuvant therapy. Our findings provide a better understanding of the potential role of hormonal therapy in relation to the cognitive dysfunction of cancer survivors.
منابع مشابه
Application of the Weibull Accelerated Failure Time Model in the Determination of Disease-Free Survival Rate of Patients with Breast Cancer
Background and Purpose: The goal of this study is application of the proportional hazards model (PH) and accelerated failure time model (AFT), with consideration Weibull distribution, to determine the level of effectiveness of the factors affecting on the level of disease-free survival (DFS) of the patients with breast cancer. Materials and Methods: Based on the retrospective descriptive stu...
متن کاملSkin Reaction in Radiation Therapy for Breast Cancer
Introduction The first medical intervention for many breast cancer patients is breast conserving surgery (BCS) and/or modified radical mastectomy (MRM). Most of these patients undergo radiation therapy, following surgery. The most common side-effect of breast radiotherapy is skin damage. In the present study, the severity of acute skin changes and the underlying causes were investigated in pati...
متن کاملمقایسه اثرات تاموکسیفن در بروز سنگهای صفراوی در بیماران زن مبتلا به کانسر پستان
Background & Aims: Tamoxifen is used in breast cancer as adjuvant hormonal therapy. Some studies have found effect of tamoxifen on bile components and gallstone formation. The purpose of the study was to find out the association between tamoxifen use in patient with breast cancer and gallstone formation. Materials & Methods: 780 patient with breast cancer who had undergone surgery in 3 hospita...
متن کاملInvestigate Change Cardiac Perfusion Pattern Following By Hypo-fractionated and Conventional Radiation Therapy Schedule in Patients with Left-Sided Breast Cancer
Introduction: Radiation-induced cardiovascular damage is a potential side effect of radiation therapy in patients with left-sided breast cancer. This prospective study compares the severity and reversibility of perfusion and functional abnormalities before, and six months after, 3D-Conformal radiation therapy treatment in left-side breast cancer patients with conventional and h...
متن کاملPostoperative antibiotic therapy after appendectomy in patients with non-perforated appendicitis
Background: Appendectomy intra-abdominal is the most frequently performed emergency surgery. This study was conducted to determine the role of postoperative antibiotics in reducing surgical site infections (SSIs) and abscess formation after open appendectomy. Methods: In the Department of Surgery, Shahid Beheshti Hospital, Babol, Iran, from October 2013 to October 2014 one hundred and fifty ...
متن کامل